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Kiyokazu Hagiwara Selected Research

Gap Junction beta-1 Protein

5/2006Inhibition of Src activity enhances the tumor-suppressive effect of the connexin 32 gene in Caki-1 renal cancer cells.
4/2005A Src family inhibitor (PP1) potentiates tumor-suppressive effect of connexin 32 gene in renal cancer cells.
2/2005Cytotoxic effect of the Her-2/Her-1 inhibitor PKI-166 on renal cancer cells expressing the connexin 32 gene.
7/2004Negative growth control of renal cell carcinoma cell by connexin 32: possible involvement of Her-2.
5/2004Hypermethylation of the CpG island of connexin 32, a candiate tumor suppressor gene in renal cell carcinomas from hemodialysis patients.
4/2004Epigenetic inactivation of connexin 32 in renal cell carcinoma from hemodialytic patients.
5/2003Down-regulation of connexin 32 gene expression through DNA methylation in a human renal cell carcinoma cell.

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Kiyokazu Hagiwara Research Topics

Disease

9Neoplasms (Cancer)
01/2008 - 01/2003
5Renal Cell Carcinoma (Grawitz Tumor)
08/2005 - 05/2003
4Kidney Neoplasms (Kidney Cancer)
05/2006 - 02/2005
3Breast Neoplasms (Breast Cancer)
11/2003 - 08/2002
2Carcinogenesis
05/2004 - 08/2002
2Ischemia
10/2002 - 01/2002
2Body Weight (Weight, Body)
08/2002 - 01/2002
1Mesothelioma
05/2009
1Hypoxia (Hypoxemia)
01/2008
1Lung Neoplasms (Lung Cancer)
01/2008
1Adenocarcinoma of Lung
07/2005
1Reperfusion Injury
01/2002

Drug/Important Bio-Agent (IBA)

7Gap Junction beta-1 ProteinIBA
05/2006 - 05/2003
6ConnexinsIBA
05/2006 - 05/2003
2TocotrienolsIBA
05/2009 - 01/2008
26-O-carboxypropyl-alpha-tocotrienolIBA
01/2008 - 07/2005
2alpha tocotrienolIBA
01/2008 - 07/2005
2Doxorubicin (Adriamycin)FDA LinkGeneric
11/2003 - 01/2003
2tocopheryloxybutyric acidIBA
11/2003 - 08/2002
2Urea (Carbamide)FDA LinkGeneric
10/2002 - 01/2002
2CreatinineIBA
10/2002 - 01/2002
2NitrogenIBA
10/2002 - 01/2002
1Cytotoxins (Cytolysins)IBA
05/2009
1PlasminogenIBA
01/2008
1Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
01/2008
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
08/2005
1Phosphotransferases (Kinase)IBA
08/2005
1src-Family KinasesIBA
08/2005
1alpha-TocopherolFDA Link
07/2005
1Antineoplastic Agents (Antineoplastics)IBA
07/2005
1PKI 166IBA
02/2005
1GenisteinIBA
01/2003
1IsoflavonesIBA
01/2003
1Dinoprostone (PGE2)FDA Link
08/2002
14- (N- methyl- N- nitrosamino)- 1- (3- pyridyl)- 1- butanoneIBA
08/2002
1Linoleic Acid (Linoleate)IBA
08/2002
1ErbB-2 ReceptorIBA
08/2002
1Proliferating Cell Nuclear Antigen (PCNA)IBA
08/2002
1Oleic Acid (Oleate)IBA
08/2002
1Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA
08/2002
1Glutathione (Reduced Glutathione)IBA
01/2002
1Heme Oxygenase-1IBA
01/2002
1Proteins (Proteins, Gene)FDA Link
01/2002

Therapy/Procedure

2Drug Therapy (Chemotherapy)
11/2003 - 01/2003
1Renal Dialysis (Hemodialysis)
05/2004